Selected Publications

Rey S, Ohm H, Moschref F, Zeuschner D, Praetz M, Klämbt C ( ): "Glial-dependent clustering of voltage-gated ion channels in Drosophila precedes myelin formation" Elife 6:12:e85752 | Abstract | Full Article
Pogodalla N, Kranenburg H, Rey S, Rodrigues S, Cardona A , Klämbt C ( ): "Drosophila ßHeavy-Spectrin is required in polarized ensheathing glia that form a diffusion-barrier around the neuropil" Nature communications 12 6357 | Abstract
Winkler B, Funke D, Benmimoun B, Speder P , Rey S, Logan M, Klämbt C ( ): "Brain inflammation triggers macrophage invasion across the blood-brain barrier in Drosophila during pupal stages" Science Advances 7 eabh0050 | Abstract
Kottmeier R, Bittern J, Schoofs A, Scheiwe F, Matzat T, Pankratz M, Klämbt C ( ): "Wrapping glia regulates neuronal signaling speed and precision in the peripheral nervous system of Drosophila" Nature communications 11 (1), 4491 | Abstract | Full Article
Petri J, Syed MH, Rey S, Klämbt C ( ): "Non-cell autonomous function of the GPI-anchored protein Undicht during septate junction assembly" Cell Reports 26 (6), 1641-1653 | Abstract
Babatz F, Naffin E, Klämbt C ( ): "The Drosophila Blood-Brain Barrier Adapts to Cell Growth by Unfolding of Pre-existing Septate Junctions" Developmental Cell 17 (47), 697-710 | Abstract | Full Article
Otto N, Marelia Z, Schoofs A, Kranenburg H, Bittern J, Yildirim K, Berh D, Bethke M, Thomas S, Rode S, Risse B, Jiang X, Pankratz M, Leimkühler S, Klämbt C ( ): "The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia" Nature communications 29 (9), 3514 | Abstract | Full Article
Zülbahar S, Sieglitz F , Kottmeier R, Altenhein B, Rumpf S, Klämbt C ( ): "Differential expression of Öbek controls ploidy in the Drosophila blood-brain barrier" Development 145 1-11 | Abstract | Full Article
Neuert H, Yuva-Aydemir Y, Silies M, Klämbt C ( ): "Different modes of APC/C activation control growth and neuron-glia interaction in the developing Drosophila eye" Development (144), 4673-4683 | Abstract | Full Article
Risse B, Berh D, Otto N, Klämbt C, Jiang X ( ): "FIMTrack: An open source tracking and locomotion analysis software for small animals" PLoS Comput Biol 11 (5), e1005530 | Abstract | Full Article
Sasse S, Klämbt C ( ): "Repulsive epithelial cues direct glial migration along the nerve" Developmental Cell 39 (6), 696-707 | Abstract | Full Article
Otto N, Risse B, Berh D, Bittern J, Jiang X, Klämbt C ( ): "Interactions among Drosophila larvae before and during collision." Sci Rep. 11 (6), 31564 | Abstract | Full Article
Risse B, Otto N, Berh D, Jiang X, Kiel M, Klämbt C ( ): "FIM2c : A Multi-Colour, Multi-Purpose Imaging System to Manipulate and Analyse Animal Behaviour." IEEE Trans Biomed Eng. | Abstract | Full Article
Halberg KA, Rainey SM, Veland IR, Neuert H, Dornan AJ, Klämbt C, Davies SA, Dow JA ( ): "The cell adhesion molecule Fasciclin2 regulates brush border length and organization in Drosophila renal tubules." Nat Commun. 3 (7), 11266 | Abstract | Full Article
Volkenhoff A, Weiler A, Letzel M, Stehling M, Klämbt C, Schirmeier S ( ): "Glial Glycolysis Is Essential for Neuronal Survival in Drosophila." Cell Metab. 22 (3), 437-47 | Abstract | Full Article
Bauke AC, Sasse S, Matzat T, Klämbt C ( ): " A transcriptional network controlling glial development in the Drosophila visual system." Development 142 (12), 2184-93 | Abstract | Full Article
Matzat T , Sieglitz F , Kottmeier R, Babatz F, Engelen D, Klämbt C ( ): "Axonal wrapping in the Drosophila PNS is controlled by glia-derived neuregulin homolog Vein" Development 142 (7), 1336-45 | Abstract | Full Article
Risse B, Otto N, Berh D, Jiang X, Klämbt C ( ): "FIM imaging and FIMtrack: two new tools allowing high-throughput and cost effective locomotion analysis." J Vis Exp. 94 | Abstract | Full Article
Kim SN, Jeibmann A, Halama K, Witte HT, Wälte M, Matzat T, Schillers H, Faber C, Senner V, Paulus W, Klämbt C ( ): "ECM stiffness regulates glial migration in Drosophila and mammalian glioma models." Development 141 (16), 3233-42 | Abstract | Full Article
Sieglitz F, Matzat T, Yuva-Aydemir Y, Neuert H, Altenhein B, Klämbt C ( ): "Antagonistic feedback loops involving Rau and Sprouty in the Drosophila eye control neuronal and glial differentiation." Sci Signal 6 (300), ra96 | Abstract | Full Article
Risse B, Thomas S, Otto N, Löpmeier T, Valkov D, Jiang X, Klämbt C ( ): "FIM, a novel FTIR-based imaging method for high throughput locomotion analysis." PLoS One 8 (1), e53963 | Abstract | Full Article
Schmidt I, Thomas S, Kain P, Risse B, Naffin E, Klämbt C ( ): "Kinesin heavy chain function in Drosophila glial cells controls neuronal activity." J Neurosci. 32 (22), 7466-76 | Abstract | Full Article
Rodrigues F, Thuma L, Klämbt C ( ): "The regulation of glial-specific splicing of Neurexin IV requires HOW and Cdk12 activity." Development 139 (10), 1765-76 | Abstract | Full Article
Syed MH, Krudewig A, Engelen D, Stork T, Klämbt C ( ): "The CD59 family member Leaky/Coiled is required for the establishment of the blood-brain barrier in Drosophila." J Neurosci. 31 (21), 7876-85 | Abstract | Full Article
Silies M, Klämbt C ( ): "APC/C(Fzr/Cdh1)-dependent regulation of cell adhesion controls glial migration in the Drosophila PNS." Nat Neurosci. 13 (11), 1357-64 | Abstract | Full Article
Klämbt C ( ): "Modes and regulation of glial migration in vertebrates and invertebrates." Nat Rev Neurosci. 10 (11), 769-79 | Abstract | Full Article
Franzdóttir SR, Engelen D , Yuva-Aydemir Y , Schmidt I , Aho A, Klämbt C ( ): "Switch in FGF signalling initiates glial differentiation in the Drosophila eye." Nature 460 (7256), 758-61 | Abstract | Full Article
Stork T , Thomas S , Rodrigues F, Silies M, Naffin E , Wenderdel S, Klämbt C ( ): "Drosophila Neurexin IV stabilizes neuron-glia interactions at the CNS midline by binding to Wrapper." Development 136 (8), 1251-61 | Abstract | Full Article
Stork T , Engelen D, Krudewig A, Silies M, Bainton RJ, Klämbt C ( ): "Organization and function of the blood-brain barrier in Drosophila." J Neurosci. 28 (3), 587-97 | Abstract | Full Article
Stork T, Engelen D, Krudewig A, Silies M, Bainton RJ, Klämbt C ( ): "Organization and function of the blood-brain barrier in Drosophila" J Neurosci. 28 (3), 587-97 | Abstract | Full Article
Silies M, Yuva Y, Engelen D, Aho A, Stork T, Klämbt C ( ): "Glial cell migration in the eye disc." J Neurosci. 27 (48), 13130-9 | Abstract | Full Article
Hülsmeier J, Pielage J, Rickert C, Technau GM, Klämbt C , Stork T ( ): "Distinct functions of alpha-Spectrin and beta-Spectrin during axonal pathfinding." Development 134 (4), 713-22 | Abstract | Full Article
Edenfeld G, Volohonsky G, Krukkert K, Naffin E, Lammel U, Grimm A, Engelen D, Reuveny A, Volk T, Klämbt C ( ): "The splicing factor crooked neck associates with the RNA-binding protein HOW to control glial cell maturation in Drosophila." Neuron 52 (6), 969-80 | Abstract | Full Article
Bogdan S, Stephan R, Löbke C, Mertens A, Klämbt C ( ): "Abi activates WASP to promote sensory organ development." Nat Cell Biol. 7 (10), 977-84 | Abstract | Full Article
Pielage J, Stork T, Bunse I, Klämbt C ( ): "The Drosophila cell survival gene discs lost encodes a cytoplasmic Codanin-1-like protein, not a homolog of tight junction PDZ protein Patj" Dev Cell 5 (6), 841-51 | Abstract | Full Article
Roos J, Hummel T, Ng N, Klämbt C, Davis G ( ): "Drosophila Futsch regulates synaptic microtubule organization and is necessary for synaptic growth" Neuron 26 (2), 371-82 | Abstract | Full Article
Hummel T, Krukkert K, Roos J, Davis G, Klämbt C ( ): "Drosophila Futsch/22C10 is a MAP1B-like protein required for dendritic and axonal development" Neuron 26 (2), 357-70 | Abstract | Full Article
Hummel T, Leifker K, Klämbt C ( ): "The Drosophila HEM-2/NAP1 homolog KETTE controls axonal pathfinding and cytoskeletal organization" Genes & Development 14 (7), 863-73 | Abstract | Full Article
Granderath S, Stollewerk A, Greig S, Goodman CS, O'Kane CJ, Klämbt C ( ): "loco encodes an RGS protein required for Drosophila glial differentiation" Development 126 (8), 1781-91 | Abstract | Full Article
Hummel T, Schimmelpfeng K, Klämbt C ( ): "Commissure formation in the embryonic CNS of Drosophila" Development 126 (4), 771-9 | Abstract | Full Article
Giesen K, Hummel T, Stollewerk A, Harrison S, Travers A, Klämbt C ( ): "Glial development in the Drosophila CNS requires concomitant activation of glial and repression of neuronal differentiation genes" Development 124 (12), 2307-16 | Abstract | Full Article
Brunner D, Dücker K, Oellers N, Hafen E, Scholz H, Klämbt C ( ): "The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway" Nature 370 (6488), 386-9 | Abstract | Full Article
Klaes A, Menne T, Stollewerk A, Scholz H, Klämbt C ( ): "The Ets transcription factors encoded by the Drosophila gene pointed direct glial cell differentiation in the embryonic CNS" Cell 78 (1), 149-60 | Abstract | Full Article
Klämbt C ( ): "The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells" Development 117 (1), 163-176 | Abstract | Full Article
Klämbt C, Glazer L, Shilo BZ ( ): "breathless, a Drosophila FGF receptor homolog, is essential for migration of tracheal and specific midline glial cells" Genes & Development 6 (9), 1668-78 | Abstract | Full Article
Freeman M, Klämbt C, Goodman CS, Rubin GM ( ): "The argos gene encodes a diffusible factor that regulates cell fate decisions in the Drosophila eye" Cell 69 (6), 963-75 | Abstract | Full Article
Klämbt C, Jacobs JR, Goodman CS ( ): "The midline of the Drosophila central nervous system: a model for the genetic analysis of cell fate, cell migration, and growth cone guidance" Cell 64 (4), 801-15 | Abstract | Full Article